|本期目录/Table of Contents|

[1]刘晨辉,徐玲玲,朱研,等.表面改性对介孔生物玻璃Ag+装载释放行为的影响[J].南京工业大学学报(自然科学版),2019,41(04):423-428.[doi:10.3969/j.issn.1671-7627.2019.04.004]
 LIU Chenhui,XU Lingling,ZHU Yan,et al.Effects of surface modification on silver ion load and release behavior of mesoporous bioglass[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2019,41(04):423-428.[doi:10.3969/j.issn.1671-7627.2019.04.004]
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表面改性对介孔生物玻璃Ag+装载释放行为的影响()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
41
期数:
2019年04期
页码:
423-428
栏目:
出版日期:
2019-07-10

文章信息/Info

Title:
Effects of surface modification on silver ion load and release behavior of mesoporous bioglass
文章编号:
1671-7627(2019)04-0423-06
作者:
刘晨辉1徐玲玲12朱研1张曹宁1吴楠1
1.南京工业大学 材料科学与工程学院,江苏 南京 211800; 2.江苏先进生物与化学制造协同创新中心,江苏 南京 211800
Author(s):
LIU Chenhui1XU Lingling12ZHU Yan1ZHANG Caoning1WU Nan1
1.College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China; 2.Jiangsu National Sybergetic Innovation Center for Advanced Materials, Nanjing 211800, China
关键词:
介孔生物玻璃 表面改性 Ag+装载 Ag+释放
Keywords:
mesoporous bioactive glass surface modification silver ion load silver ion release
分类号:
TQ171.74
DOI:
10.3969/j.issn.1671-7627.2019.04.004
文献标志码:
A
摘要:
分别使用醋酸和盐酸为催化剂制备介孔生物玻璃,记为HAc-MBG和HCl-MBG,采用X线衍射仪(XRD)、傅里叶变换红外光谱仪(FT-IR)、扫描电子显微镜(SEM)和N2吸附-脱附等方法进行分析。使用γ-氨丙基三乙氧基硅烷(A-1100)对样品进行表面氨基化改性,改性后的样品记为HAc-NMBG和HCl-NMBG。对改性前后的样品进行Ag+的装载与释放,研究表面改性对样品Ag+装载与释放行为的影响。结果表明:HAc-MBG具有更大的比表面积、孔容和平均孔径,同时具有更好的生物活性; HAc-NMBG载银量为656.7 mg/g,比HAc-MBG提高了60.01%,缓释率由0.82%降低至0.68%,缓释性能提高了17.07%。
Abstract:
Mesoporous bioglass of HAc-MBG and HCl-MBG was prepared using acetic acid and hydrochloric acid as catalysts, and was analyzed by X-ray diffraction(XRD), Fourier transform infrared spectrometry(FT-IR), scanning electron microscope(SEM), and N2 adsorption and desorption. The surfaces of the samples HAc-NMBG and HCl-NMBG were modified with NH2CH2CH2CH2Si(OC2H5)3(A-1100). The silver ions were loaded and released before and after the modification to investigate the effect of surface modification on the silver ion loading and releasebehavior. Results showed that HAc-MBG had a larger specific surface area, pore volume and average pore size, and had better biological activity. The silver loading capability of HAc-NMBG was 656.7 mg/g, which was 60.01% higher than that of HAc-MBG, the slow release ratio was reduced from 0.82% to 0.68%, and the svstained release performance was increased by 17.07%.

参考文献/References:

[1] HENCH L L.The story of bioglass [J].Journal of Materials Science Materials in Medicine,2006,17(11):967.
[2] HENCH L L,SPLINTER R J,ALLEN W C,et al.Bonding mechanisms at the interface of ceramic prosthetic materials[J].Journal of Biomedical Materials Research,1971,5(6):117.
[3] YAN X,YU C,ZHOU X,et al.Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities[J].Angewandte Chemie International Edition,2004,43(44):5980.
[4] LEE W L,LOEI C,WIOJAJA E,et al.Altering the drug release profiles of double-layered ternary-phase microparticles[J].Journal of Controlled Release,2011,151(3):229.
[5] SONG K D,LIU Y C,MACEDO H M,et al.Fabrication and evaluation of a sustained-release chitosan-based scaffold embedded with PLGA microspheres[J].Materials Science and Engineering C,2013,33(3):1506.
[6] YANG C Y,GUO W,CUI L R,et al.pH-responsive controlled-release system based on mesoporous bioglass materials capped with mineralized hydroxyapatite[J].Materials Science and Engineering C,2014,36(1):237.
[7] KAWASHITA M,TSUNEYAMA S F,MIYAJI F,et al.Antibacterial silver-containing silica glass prepared by sol-gel method[J].Biomaterials,2000,21(4):393.
[8] BALAMURUGAN A,BALOSSIER G,LAURENT-MAQUIN D,et al.An in vitro biological and anti-bacterial study on a sol-gel derived silver-incorporated bioglass system[J].Dental Materials,2008,24(10):1343.
[9] BALAMURUGAN A,SOCKALINGUM G,MICHEL J,et al.Synthesis and characterisation of sol gel derived bioactive glass for biomedical applications[J].Materials Letters,2006,60(29):3752.
[10] 王德平,黄文旵.有源无机抗菌材料的研究进展[J].建筑材料学报,2000,3(1):73.
[11] KEE G H,KANG M S,MAHAPATRA C,et al.Effect of aminated mesoporous bioactive glass nanoparticles on the differentiation of dental pulp stem cells[J].Plos One,2016,11(3):e0150727.
[12] ZHAO S,ZHANG J,ZHU M,et al.Effects of functional groups on the structure,physicochemical and biological properties of mesoporous bioactive glass scaffolds[J].Journal of Materials Chemistry B,2015,3(8):1612.
[13] KOKUBO T.Surface chemistry of bioactive glass-ceramics[J].Journal of Non-Crystalline Solids,1990,120(1):138.
[14] KOKUBO T,TAKADAMA H.How useful is SBF in predicting in vivo bonebioactivity[J].Biomaterials,2006,27(15):2907.
[15] 陈晓峰,郭常亮,赵娜如,等.溶胶-凝胶生物活性玻璃超细粉体的制备与生物矿化性能研究[J].无机材料学报,2008,23(5):1027.
[16] IZUTSU H,MIZUKAMI F,SASHIDA T,et al.Effect of malic acid on structure of silicon alkoxide derived silica[J].Journal of Non-Crystalline Solids,1997,212(1):40.
[17] YAN X,HUANG X,YU C,et al.The in-vitro bioactivity of mesoporous bioactive glasses[J].Biomaterials,2006,27(18):3396.
[18] 田英姿,陈克复.用压汞法和氮吸附法测定孔径分布及比表面积[J].中国造纸,2004,23(4):21.
[19] 崔静洁,何文,廖世军,等.多孔材料的孔结构表征及其分析[J].材料导报,2009,23(13):82.
[20] NEWALKAR B L,OLANREWAJU J,KOMARNENI S.Microwave-hydrothermal synthesis and characterization of zirconium substituted SBA-15 mesoporous silica[J].The Journal of Physical Chemistry B,2001,105(35):8356.
[21] HSU F Y,WENG R C,LIN H M,et al.A biomimetic extracellular matrix composed of mesoporous bioactive glass as a bone graft material[J].Microporous and Mesoporous Materials,2015,212:56.
[22] ZHU M,ZHANG L X,HE Q J,et al.Mesoporous bioactive glass-coated poly(L-lactic acid)scaffolds:a sustained antibiotic drug release system for bone repairing[J].Journal of Materials Chemistry,2011,21(4):1064.

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备注/Memo

备注/Memo:
收稿日期:2018-05-26
基金项目:江苏省普通高校研究生科研创新计划; 江苏高校优势学科建设工程
作者简介:刘晨辉(1993—),男,E-mail:1047851962@qq.com; 徐玲玲(联系人),教授,E-mail:xll@njtech.edu.cn.
引用本文:刘晨辉,徐玲玲,朱研,等.表面改性对介孔生物玻璃Ag+装载释放行为的影响[J].南京工业大学学报(自然科学版),2019,41(4):423-428..
更新日期/Last Update: 2019-07-20