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[1]苗燕飞,陈国广,任丽莉,等.盐酸齐拉西酮大鼠在体肠吸收动力学[J].南京工业大学学报(自然科学版),2017,39(01):133-136.[doi:10.3969/j.issn.1671-7627.2017.01.021]
 MIAO Yanfei,CHEN Guoguang,REN Lili,et al.Kinetics of in situ intestinal absorption of ziprasidone hydrochloric acid in rats[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2017,39(01):133-136.[doi:10.3969/j.issn.1671-7627.2017.01.021]
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盐酸齐拉西酮大鼠在体肠吸收动力学()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
39
期数:
2017年01期
页码:
133-136
栏目:
出版日期:
2017-01-21

文章信息/Info

Title:
Kinetics of in situ intestinal absorption of ziprasidone hydrochloric acid in rats
文章编号:
1671-7627(2017)01-0133-04
作者:
苗燕飞1陈国广2任丽莉2欧阳平凯1
1.南京工业大学 生物与制药工程学院,江苏 南京 211800; 2.南京工业大学 药学院,江苏 南京 211800
Author(s):
MIAO Yanfei1CHEN Guoguang2REN Lili2OUYANG Pingkai1
1.College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211800,China; 2.College of Pharmaceutical Sciences,Nanjing Tech University,Nanjing 211800,China
关键词:
齐拉西酮 在体肠灌流 高效液相色谱
Keywords:
ziprasidone in situ recirculation HPLC
分类号:
R969.1
DOI:
10.3969/j.issn.1671-7627.2017.01.021
文献标志码:
A
摘要:
建立灌流液中盐酸齐拉西酮含量的高效液相色谱法(HPLC),研究盐酸齐拉西酮的SD大鼠在体肠吸收动力学。采用大鼠在体单向肠灌流模型,研究盐酸齐拉西酮在不同肠段的吸收特性以及不同药物浓度和胆汁分泌对盐酸齐拉西酮吸收的影响。结果表明:盐酸齐拉西酮在大鼠全肠段均有吸收,其中十二指肠吸收大于结肠,吸收速率常数(K)分别为(4.69±0.33)和(2.61±0.37)h-1。盐酸齐拉西酮在不结扎胆管的十二指肠吸收速率大于结扎胆管。随着肠灌流液中盐酸齐拉西酮浓度的升高,吸收速率常数呈上升趋势。盐酸齐拉西酮在体的吸收方式为被动扩散。
Abstract:
The kinetics of in situ intestinal absorption of ziprasidone in SD rats was studied from analysis the content of ziprasidone in recirculation fluid with a high performance liquid chromatography(HPLC).The in situ single-way perfusion rat model was used for the absorption behaviors of ziprasidone in each intestinal segment of rats.The effect of drug concentration and the bile salt on the intestinal absorption were also investigated.Results showed that ziprasidone was absorbed in the total intestinal with the absorption rate constant(K)of duodenum of(4.69±0.33)and(2.61±0.37)h-1 in colon.The absorption rate constant in duodenum was higher with free access to bile salt compared with the bile duct ligation.With the increase of the concentration of ziprasidone,the absorption rate constant was increased.The absorption of ziprasidone occurred via the simple diffusion.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2015-06-12
基金项目:江苏省科技厅前瞻性联合研究(BY2015005-11)
作者简介:苗燕飞(1988—),男,江苏连云港人,博士,主要研究方向为药物分析及制剂; 陈国广(联系人),教授,E-mail:guoguangchenlab@163.com.
引用本文:苗燕飞,陈国广,任丽莉,等.盐酸齐拉西酮大鼠在体肠吸收动力学[J].南京工业大学学报(自然科学版),2017,39(1):133-136..
更新日期/Last Update: 2017-01-15