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[1]程爱民,刁国旺.三聚磷酸钠改性聚氨酯纳米粒子的合成及表征[J].南京工业大学学报(自然科学版),2016,38(06):51-56.[doi:10.3969/j.issn.1671-7627.2016.06.009]
 CHENG Aimin,DIAO Guowang.Synthesis and characterization of polyurethane nanoparticles modified by sodium tripolyphosphate[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2016,38(06):51-56.[doi:10.3969/j.issn.1671-7627.2016.06.009]
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三聚磷酸钠改性聚氨酯纳米粒子的合成及表征()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
38
期数:
2016年06期
页码:
51-56
栏目:
出版日期:
2016-11-15

文章信息/Info

Title:
Synthesis and characterization of polyurethane nanoparticles modified by sodium tripolyphosphate
文章编号:
1671-7627(2016)06-0051-06
作者:
程爱民1刁国旺2
1.扬州市职业大学 生物与化工工程学院,江苏 扬州 225009; 2. 扬州大学 化学化工学院,江苏 扬州 225002
Author(s):
CHENG Aimin1DIAO Guowang2
1.College of Biological and Chemical Engineering,Yangzhou Polytechnic College,Yangzhou 225009,China; 2. College of Chemistry & Chemical Engineering,Yangzhou University,Yangzhou 225002,China
关键词:
聚氨酯纳米粒子 三聚磷酸钠 细胞毒性实验
Keywords:
polyurethane nanoparticles sodium triphosphate cytotoxicity-test
分类号:
O63
DOI:
10.3969/j.issn.1671-7627.2016.06.009
文献标志码:
A
摘要:
以二苯基甲烷-4,4’-二异氰酸酯(MDI)、聚四氢呋喃醚二醇(PTMG)为主要原料,二羟基甲基丙酸(DMPA)作为功能单体,异丙醇作为封端剂,并以三乙胺中和,制得聚氨酯离聚物(PUI)。再用十二烷基硫酸钠溶液以及三聚磷酸钠(STP)溶液处理,制得表面修饰的聚氨酯粒子(PUI-STP)。用透射电子显微镜(TEM)、扫描电子显微镜(SEM)、马尔文粒度分布仪、核磁共振仪(NMR)及X线光电子能谱仪(XPS)对样品进行表征。结果表明:粒子为圆球形,大小较为均一,平均粒径为179.2 nm,达到了纳米尺度,且PUI-STP中增加了大量P元素,说明三聚磷酸根已经被成功引入到聚氨酯纳米粒子表面。红细胞体外试验结果表明该纳米粒子具有良好的血液相容性,细胞毒性实验结果表明该纳米粒子具有良好的细胞相容性。
Abstract:
Polyurethane ionomers(PUI)were prepared based on 4, 4’-diphenylmethane diisocyanate(MDI), polytetramethylene ether glycol(PTMG)and dimethylol propionic acid(DMPA). The resultant ionomers were then treated in sodium dodecyl sulfate(SDS)solution and sodium triphosphate(STP)solution for preparing polyurethane nanoparticles with sodium tripolyphosphate(PUI-STP). The samples were characterized by transmission electron microscope(TEM), scanning electron microscope(SEM), Malvern laser analyzer, nuclear magnetic resonance(NMR)and X-ray photoelectron spectroscopy(XPS). Results showed that the prepared particles were spherical with an average particle size of 179.2 nm. A considerable amount of P element was detected in PUI-STP, indicating that triphosphate had been successfully introduced on the surfaces of the polyurethane nanoparticles. Red blood cell morphology and the in vitro cytotoxicity-test indicated that the PU-STP nanoparticles had excellent blood compatibility and good cell compatibility.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2016-04-12
基金项目:江苏省高等职业院校国内高级访问学者计划(FX013)
作者简介:程爱民(1968—),男,江苏泰兴人,副教授,硕士,主要研究方向为聚氨酯复合材料,E-mail:yzcham@126.com.
引用本文:程爱民,刁国旺.三聚磷酸钠改性聚氨酯纳米粒子的合成及表征[J].南京工业大学学报(自然科学版),2016,38(6):51-56..
更新日期/Last Update: 2016-12-20