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[1]罗芳,汤杰,陈虹月,等.多巴胺修饰制备亲水性NaYF4:Yb,Er上转换发光纳米颗粒[J].南京工业大学学报(自然科学版),2016,38(06):26-31.[doi:10.3969/j.issn.1671-7627.2016.06.005]
 LUO Fang,TANG Jie,CHEN Hongyue,et al.Preparation of hydrophilic NaYF4:Yb,Er up-conversion nanoparticles by dopamine surface modification[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2016,38(06):26-31.[doi:10.3969/j.issn.1671-7627.2016.06.005]
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多巴胺修饰制备亲水性NaYF4:Yb,Er上转换发光纳米颗粒()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
38
期数:
2016年06期
页码:
26-31
栏目:
出版日期:
2016-11-15

文章信息/Info

Title:
Preparation of hydrophilic NaYF4:Yb,Er up-conversion nanoparticles by dopamine surface modification
文章编号:
1671-7627(2016)06-0026-06
作者:
罗芳1汤杰2陈虹月1胡仿香1黄和1韩毓旺2
1.南京工业大学 生物与制药工程学院,江苏 南京 210009; 2.南京工业大学 化学与分子工程学院,江苏 南京 210009
Author(s):
LUO Fang1TANG Jie2CHEN Hongyue1HU Fangxiang1HUANG He1HAN Yuwang2
1.College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 210009,China; 2.College of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 210009,China
关键词:
NaYF4:YbEr 上转换发光纳米颗粒(UCNPs) 多巴胺(DA) 表面修饰 亲水性
Keywords:
NaYF4:YbEr up-conversion nanoparticles(UCNPs) dopamine(DA) surface modification the hydrophilic
分类号:
O614
DOI:
10.3969/j.issn.1671-7627.2016.06.005
文献标志码:
A
摘要:
稀土上转换发光纳米材料在生物领域应用的前提是具有亲水性和可以偶联蛋白的官能团。先将十六烷基三甲基溴化铵(CTAB)中的碳链通过疏水作用插入到溶剂热法制备的NaYF4:Yb,Er纳米粒子表面油酸分子中,然后通过多巴胺(DA)在其表面氧化聚合形成具有氨基的亲水性纳米粒子(UCNPs@DA)。分别采用透射电子显微镜(TEM)、傅里叶变换红外光谱(FT-IR)、光纤光谱对其形貌、表面官能团和上转发光性能进行了表征与分析。考察了在修饰过程中DA的质量浓度、滴加速度等因素对形成UCNPs@DA的影响。结果表明,当DA质量浓度为0.20 mg/mL、滴加速度为1.25 mL/min时,试样具有较好水中分散性及发光效率。UCNPs@DA 在540 nm处的发光强度是未修饰试样的70%,而650 nm处的光强未发生衰减。UCNPs@DA有望成为生物检测中很好的发光标志物。
Abstract:
Good hydrophilicity and appropriate functional group are the prerequisites for bio-applications of up-conversion nanoparticles(UCNPs).The long carbon chain of hexadecyl trimethyl ammonium bromide(CTAB)was inserted into the oleic acid molecules on the surface of solvothermally synthesized NaYF4:Yb,Er through hydrophobic interaction.This activated NaYF4:Yb,Er nanoparticles were then converted to water soluble and amine group bearing one(UCNPs@DA)through oxidative polymerization of dopamine(DA).The morphologies,surface functional groups and luminescence properties of NaYF4:Yb,Er samples were characterized by transmission electron microscope(TEM), Fourier transform infrared spectrometer(FT-IR)and upconversion luminescence spectrum.The effects of DA solution mass concentration and its dropping speed were investigated in details. UCNPs@DA with good hydrophilicity and luminescence property was obtained using a 0.20 mg/mL DA solution at a dropping speed of 1.25 mL/min. After DA modification,about 70% of original luminescence at 540 nm was preserved while the light intensity at 650 nm remained unchanged.The UCNPs@DA could act as a good label for biological detection.

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备注/Memo

备注/Memo:
收稿日期:2015-04-18
基金项目:国家杰出青年科学基金(21225626); 国家自然基金(20936002); 国际科技合作项目(2012DFA51050); 江苏省博士科技创新项目(CXZZ12-0437)
作者简介:罗芳(1989—),女,陕西西安人,硕士,主要研究方向为稀土上转换纳米材料的制备及其在免疫检测上的应用; 韩毓旺(联系人),教授,E-mail:hanyw@njtech.edu.cn.
引用本文:罗芳,汤杰,陈虹月,等.多巴胺修饰制备亲水性NaYF4:Yb,Er上转换发光纳米颗粒[J].南京工业大学学报(自然科学版),2016,38(6):26-31..
更新日期/Last Update: 2016-12-20